Solvent-free synthesis of new chalcone derivatives from 3-nitro phthalic acid and evaluation of their biological activities

Synthesis of 2-(4-Acetyl-phenyl)-4-nitro-isoindole-1, 3-dione chalcones were performed by fusion 3-nitro phthalic anhydride with p-aminoacetophenone. Then the later was grinded different aromatic aldehydes in presence sodium hydroxide to produce new derivatives A3-10 without using any solvent formation N-arylphthailimide confirmed FTIR,1HNMR, 13CNMR spectroscopy and all final compounds tested for their antifungal antibacterial activity some them showed more biological than standard drugs..